Johns Hopkins Cleft & Cranial Facial Center


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Cleft and Craniofacial Research at Johns Hopkins

Scientist at Johns Hopkins are performing ground breaking research into the environmental and genetic causes of cleft lip and palate and other craniofacial disorders. Below is a list of selected publications from our Genetic Epidemiology of Oral Clefts group.

 

 

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Hwang SJ, Beaty TH, Panny SR, Street NA, Joseph JM, Gordon S, McIntosh I, Francomano CA.  Association study of transforming growth factor alpha (TGF_) TaqI polymorphism and oral clefts: Indication of gene-environment interaction in a population based sample of infants with birth defects.  AM J EPIDEM 141:629-636, 1995.

Wyszynski DF, Beaty TH.  Review of the role of potential teratogens in the origin of human non-syndromic oral clefts.  TERATOLOGY 53:309-317, 1996.

Wyszynski DF, Beaty TH, Maestri NE.  Genetics of non-syndromic oral clefts revisited. CLEFT PALATE- CRANIOFACIAL J 33:406-417, 1996

Wyszynski DF, Lewanda A, Beaty TH.  Phenotypic discordance in a family with monozygotic twins and non-syndromic cleft lip and palate (Letter to the editor).  AM J MED GENET 66:468-470, 1996

Wyszynski DF, Maestri N, McIntosh I, Smith EA, Lewanda AF, Garcia-Delgado C, Vinageras-Guarneros, Wulfsberg E, Beaty TH.  Evidence for an association between markers on chromosome 19q and non-syndromic cleft lip with or without cleft palate in two groups of multiplex families.  HUM GENET 99:22-26, 1997.

Wyszynski DF, Maestri NE, Lewanda A, McIntosh I, Smith EA, Garcia-Delgado C, Vinageras-Guarneros E, Wulfsberg E, Beaty TH.  No evidence of linkage of cleft lip with or without cleft palate to a marker near the transforming growth factor-alpha (TGF_) locus in two populations.  HUM HERED 47:101-109, 1997.

Wyszynski DF, Duffy DL, Beaty TH.  Maternal cigarette smoking and oral clefts.  A meta-analysis.  CLEFT PALATE-CRANIOFACIAL J 34;3:206-210, 1997.

Beaty TH, Maestri NE, Hetmanski JB, Wyszynski DF, Vanderkolk CA, Simpson JC, McIntosh I, Smith EA, Zeiger JS, Raymond GV, Panny SR, Tifft CJ, Lewanda AF, Cristion CA, Wulfsberg EA.  Testing for interaction between maternal smoking and TGFA genotype among oral clefts cases born in Maryland 1992-1996.  CLEFT PALATE-CRANIOFACIAL J 34:447-454, 1997.

Maestri NE, Beaty TH, Hetmanski JB, Smith A, McIntosh I, Wyszynski DF, Liang KY, Duffy DL, Vanderkolk CA.  Application of transmission disequilibrium tests to nonsyndromic oral clefts: Including candidate genes and environmental exposures in the models.  AM J MED GENET 73:337-344, 1997.

Wyszynski DF, Zeiger J, Tilli MT, Bailey-Wilson JE, Beaty TH.  Survey of genetic counselors and clinical geneticists regarding recurrence risks for families with nonsyndromic cleft lip with/without cleft palate.  AM J MED GEN 79:184-190, 1998.

Beaty TH, Wang H, Hetmanski JB, Fan YT, Zeiger JS, Liang KY, Chiu YF, VanderKolk CA, Seifert KC, Wulfsberg EA, Raymond G, Panny SR, McIntosh I.  A case-control study of non-syndromic oral clefts in Maryland.  ANN EPIDEM 11:434-442, 2001.

Beaty TH, Hetmanski JB, Zeiger JS, Fan YT, Liang KY, VanderKolk CA, McIntosh I.  Testing candidate genes for oral clefts using the case-parent trio design.  GENET EPI 22:1-11, 2002.

Mitchell LE, Beaty TH, Lidral AC, Munger RG, Murray JC, Saal HM, Wyszynski DF.  Guidelines for the design and analysis of studies on non-syndromic cleft lip and cleft palate in humans.  CLEFT PALATE-CRANIO J 39:93-100, 2002.

Wyszynski DF, Beaty TH.  Phenotypic discordance in a family with monozygotic twins and nonsyndromic cleft lip and palate: Follow-up. AM J MED GENET 110:182-183, 2002.

Zeiger JS, Beaty TH.  Is there a relationship between risk factors for oral clefts?  TERATOLOGY 66:205-208, 2002.

Fallin MD, Hetmanski JB, Park J, Scott AF, Ingersoll R, Fuernkranz HA, McIntosh I, Beaty TH.  Family-based analysis of MSX1 haplotypes for association with oral clefts.  GENET EPI 25:168-175, 2003.

Wyszynski DF, Hejazi-Albacha H, Aldirani M, Hammod M, Shkair H, Karam A, Alashkar J, Holmes TN, Pugh EW, Doheny KF, McIntosh I, Beaty TH, Bailey-Wilson JB.  A genome-wide scan for loci predisposing to non-syndromic cleft lip with or without cleft palate in two large Syrian families.  AM J MED GENET 123A:140-147, 2003.

Zeiger JS, Hetmanski JB, Beaty TH, VanderKolk CA, Wsyzynski DF, Bailey-Wilson JE, Ortiz de Luna R, Perandones C, Tolarova MM, Mosby T, Bennun R, Segovia M, Calda P, Pugh EW, Koheny K, McIntosh, I.  Evidence for linkage of non-syndromic cleft lip and palate to a region on chromosome 2.   EUR J HUM GENET 11(11):835-839,  2003.

Marazita ML, Murray JC, Lidral AC, Arcos-Burgos M, Cooper ME, Goldstein T, Maher BS, Daack-Hirsch S, Schultz R, Field LL, Liu Y, Prescott N, Malcolm S, Winter R, Ray A, Moreno L, Valencia C, Neiswanger K, Wyszynski DF, Bailey-Wilson JE, Albacha-Hejazi H, Beaty TH, McIntosh I, Hetmanski JB, Tuncbilek G, Edwards M, Harkin L, Scott R, Roddick LG.  Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35.  AM J HUM GENET 75:161-173, 2004.

Zeiger JS, Beaty TH, Liang KY.  Oral clefts, maternal smoking and TGFA: Meta-analysis of gene-environment interaction.  CLEFT PALATE-CRANIOFACIAL  J 42(1): 58-63, 2005.

 
 

 

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